Immunology
IFN-alpha priming results in a gain of proinflammatory function by IL-10
Published in Gene Therapy Weekly, July 22nd, 2004
According to published research from the United States, "Interleukin-10 is a predominantly anti-inflammatory cytokine that inhibits macrophage and dendritic cell function, but can acquire proinflammatory activity during immune responses. We investigated whether type I IFNs, which are elevated during infections and in autoimmune diseases, modulate the activity of IL-10."
"Priming of primary human macrophages with low concentrations of IFN-alpha diminished the ability of IL-10 to suppress TNF-alpha production. IFN-alpha conferred a proinflammatory gain of function on IL-10,...
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Source: Gene Therapy Weekly (2004-07-22)
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