Molecular Targets
Polo-like kinase 1 suppression arrests the growth of pancreatic cancer cells
Published in Gene Therapy Weekly, July 22nd, 2004
According to published research from the United States, "pancreatic cancer is the fourth leading cause of cancer-related death in adults in the United States. New molecular targets for diagnosis and therapy of this disease are desperately needed. In this study, we report on the mitotic serine-threonine kinase polo-like kinase 1 (Plk1) in pancreatic cancer."
"Plk1 mRNA was found to be overexpressed in 9 of 10 tested pancreatic cancer cell lines and in 4 of 4 tested human tumors. Immunohistochemical staining of a pancreatic tissue microarray showed that 26 of the 35 tumors...
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Source: Gene Therapy Weekly (2004-07-22)
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