Published in Gene Therapy Weekly, July 22nd, 2004
"Gene-based delivery can establish a sustained supply of therapeutic proteins within the nervous system. For diseases characterized by extensive central nervous system (CNS) and peripheral nervous system (PNS) involvement, widespread distribution of the exogenous gene may be required, presenting a challenge to in vivo gene transfer strategies," according to scientists in Italy.
"Here, using lentiviral vectors (LVs), we efficiently transduced hematopoietic stem cells (HSCs) ex vivo and evaluated the potential of their progeny to target therapeutic genes to the CNS and PNS of...
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