Bacterial Infection

C. pneumoniae-induced IFN-gamma dependent on 88-IFN-alpha beta-STAT1 signaling

Published in Gene Therapy Weekly, July 22nd, 2004

C. pneumoniae-induced IFN-gamma is dependent on 88-IFN-alpha beta-STAT1 signaling.

"Infection of murine bone marrow-derived macrophages (BMMphi(P) with Chlamydia pneumoniae induces IFN-alphabeta-dependent IFN-gamma secretion that leads to control of the intracellular bacterial growth. Enhanced growth of C. pneumoniae in Toll-like receptor (TLR) 4-/- and myeloid differentiation factor (MyD) 88-/- (but not TLR2-/-, TLR6-/-, or TLR9-/-) BMMphi) is shown in this study," researchers in Sweden report.

"Reduced accumulation of IFN-alpha and IFN-gamma mRNA was also observed in TLR4-/- and MyD88-/- -infected cells. IL-1R and IL-18R...

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Source: Gene Therapy Weekly (2004-07-22)

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