Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . July 29th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Drug Resistance - Bcl-2 antisense agent G3139 invokes a response to refractory multiple myeloma
Gene Regulation - Modified nucleotides defeat barriers to RNA inaccessibility
Gene Transfer - An overnight transduction protocol prepares repopulating cells for transfer
Genetic Engineering - New compounds coax embryonic stem cells into cardiac differentiation
Immunology - CD40 ligand gene therapy halts Th2-mediated tumor escape
Bioengineering - Re-engineered coagulation factor will improve hemophilia A gene therapy
Bronchoalveolar Carcinoma - Phase II trial of GVAX lung cancer vaccine begins
Business Update - AstraZeneca selects preferred supplier of siRNA
Cancer Therapy - DNA methylation shows promise for treating advanced prostate cancer
Clinical Genetics - Genetic profiling has advanced our knowledge of non-small cell lung cancer
Collaborations - Applied Biosystems to collaborate on human gene study with Spotfire
Collaborations - Europroteome enters molecular profiling collaboration
DNA Vaccine - Heat-shock protein as dendritic cell target enhances vaccine potency
Diagnostics - Medical diagnostics company signs Brazillian research agreement
Drug Design - Research accelerates discovery of novel gene function
Drug Development - Direct versus indirect genotoxicity classifies pharmaceuticals
Drug Development - The novel Escherichia coli YeiK gene product is a gene therapy candidate
Gastroenterology - Neuropilin-1 is an angiogenesis induction factor in human colon cancers
Gene Assembly - Escherichia coli vectors host the synthesis of recombinant human interferon
Gene Expression - HIV-1 Tip110 is a negative regulator of AR transcriptional activation
Gene Expresssion - TCR signaling inhibits apoptosis by repressing SRG3 via Ras activation
Gene Silencing - Hairpin structures of double-stranded RNA produce RNA interference
Gene Transfer - Antisense reduction of connective tissue growth factor curtails renal injury
Gene Transport - Karyopherin 13 is a paired-type homeodomain transcription factor importer
Genetics - Harvard patent on genetically altered mouse upheld
Genetics - Mother learns family 'curse' has genetic origin
Geriatrics - Immune reporters monitor young fruit flies for remaining life span
HIV/AIDS Therapy - Protamine/AS-ODN nanoparticles may be used to inhibit HIV gene expression
Hemophilia - Selective targeting helps lentiviral vectors establish gene expression
Human Papillomavirus - Study suggests first molecular target to halt spread of HPV
Huntington Disease - Combination of gene therapy, gene silencing prevents neurodegenerative disease
Immunology - Erythropoietin gene therapy causes autoimmune anemia in animal studies
Mergers and Acquisitions - Synthetic DNA business unit sold to Operon Biotechnologies
Neurodegeneration - Iris pigment epithelial cells show promise as neurotrophic gene vectors
Nucleotide Selection - A new method offers rapid purification of RNA
Obesity - Leptin and its receptor may promote immune dysfunction related to obesity/NHL
Pancreatic Cancer - Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer
Patents - Company wins patent for detecting genetic variants utilizing base stacking
Personnel - Gerhard Baumgartner joins Chemophase maker's scientific advisory board
Personnel - Max Link elected chairman of antibody development company
Pulmonary Disease - Digitoxin might prevent the cytokine-mediated inflammation of cystic fibrosis
Pulmonary Medicine - Nucleotide insertions reverse the cystic fibrosis phenotype in tissue cultures
Recombinant - Endostatin requires E-selectin for angiogenesis inhibition
Renal Disease - Differential inhibition of major heat shock proteins modifies cell injury
Restructuring - Drug-discovery company to focus resources on expanding clinical pipeline
Stem Cell Research - Hoxb4 is essential for the normal proliferation of hematopoietic progenitors
Stem Cell Research - Leader says Senate has enough votes for more liberal stem cell research policy
Stem Cell Research - Stem cell transplantation reverses canine leukocyte adhesion deficiency
Stem Cell Transplantation - Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT
Stem-Cell Research - L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions
Stem-Cell Research - SCL required for normal function of short-term repopulating hematopoietic SCs
Stem-Cell Research - Type I HBEC immortalization may be early step in breast cancer subset initiation
Thrombosis - CD39 regulatory mechanisms prevent thrombotic events in transgenic mice
Transfection - The transfectant pDMAEMA does not disrupt endosomes after internalization
Vascular Disease - Origins of blood vessel cells discovered
Vector Development - Human serum albumin nanoparticles deliver antisense nucleotides to tumor cells
Vectors and Zoonoses - Epitope knock-down increases zoonosis risk from gene-modified pig transplants
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