Gene Regulation
Modified nucleotides defeat barriers to RNA inaccessibility
Published in Gene Therapy Weekly, July 29th, 2004
According to recent research published in the Journal of Molecular Biology, "antisense oligonucleotides and ribozymes have been used widely to regulate gene expression by targeting mRNAs in a sequence-specific manner. Long RNAs, however, are highly structured molecules. Thus, up to 90% of putative cleavage sites have been shown to be inaccessible to classical RNA based ribozymes or DNAzymes."
"Here, we report the use of modified nucleotides to overcome barriers raised by internal structures of the target RNA. In our attempt to cleave a broad range of picornavirus RNAs, we generated a...
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Source: Gene Therapy Weekly (2004-07-29)
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