Renal Disease
Endogenous antisense transcripts regulate nephrin expression
Published in Gene Therapy Weekly, August 5th, 2004
According to a study from Finland, "mutations of NPHS1, the gene encoding the kidney glomerular filtration barrier protein nephrin, cause congenital nephrotic syndrome of the Finnish type. Nephrin is a component of the interpodocyte-spanning slit diaphragm: it mediates outside-in signaling and forms a nexus for homo- and heterotypic molecular interactions."
"When studying the nephrin-deficient mouse line generated by random insertional mutagenesis we unexpectedly discovered an endogenous antisense transcript originating from the nephrin-en coding locus," said P. Ihalmo and colleagues,...
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Source: Gene Therapy Weekly (2004-08-05)
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