Gene Therapy

HSV immortalized T cells are gene therapy model for primary immunodeficiencies

Published in Gene Therapy Weekly, August 19th, 2004

Herpesvirus saimiri immortalized T cells are a gene therapy model for primary immunodeficiencies.

"Infection of human T lymphocytes with the Herpesvirus saimiri (HVS) yields immortalized T-cell lines (HVS-T) which retain all the phenotypical and functional characteristics of their parental cells. This represents a new experimental model for studying genetic disorders of T lymphocytes.

"In spite of the efforts of many laboratories, no satisfactory way has been found so far to modify HVS-T cells genetically," scientists writing in the journal Gene Therapy report.

"We have analyzed the capacity of oncoretroviral (MLV)- and...

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Source: Gene Therapy Weekly (2004-08-19)

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