Immunology
Cytotoxic T cell induction enhances humoral response after DNA immunization
Published in Gene Therapy Weekly, August 26th, 2004
According to recent research published in the journal Blood, "Although there are many examples (e.g., immune deviation) in which enhanced cellular responses correspond with lower humoral responses, here we demonstrate for the first time two models in which cytotoxic T-lymphocyte (CTL) activity is associated with an enhanced antibody response. First, C57BL/6 mice generate a stronger antibody response to ovalbumin DNA immunization than congenic bm1 mice. The latter differ from C57BL/6 mice in that the H-2Kb molecule is mutated so that the...
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Source: Gene Therapy Weekly (2004-08-26)
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