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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . September 9th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Fetal Medicine - In utero gene delivery may be capable of treating muscular dystrophy

Oncovirus - Recombinant Sendai virus selects for and lyses human tumor cells

Pulmonary Medicine - Secretory leukoprotease inhibitor can be targeted for treating lung cancer

Type 1 Diabetes - Vascular endothelial growth factor gene delivery promotes islet vessel growth

Urology - Histone deacetylase inhibitors improve the transfection of bladder cancer cells

Addiction Medicine - Researchers find new hope for detecting gene doping

Anticancer Therapy - Gene-deleted oncolytic adenovirus vector activates cancer therapy

Bioengineering - Delta LNGFR is a viable gene marker in engineered tissues

Bioinformatics - The new siRNA Selection Server automates short oligonucleotide design

Biotechnology - Optical biosensor addresses a whole bioprocess in real time

Breast Cancer - EGR3 involved in estrogen-signaling pathway in breast cancer

Breast Cancer - gamma Synuclein stimulates hormone-responsive mammary tumorigenesis

Cancer Therapy - BNO69 angiogenesis gene discovery published in journal

Cervical Cancer - New DNA vaccine targets proteins expressed in cervical cancer cells

Collaborations - Neugene antisense deal inked with USAMRIID on biodefense agents

Colon Cancer - Hyaluronan pairs with CD44 to encourage colon carcinoma cell invasion

Cytomegalovirus - Gene transfer used to activate CMV specific T cells

Diabetic Nephropathy - Transforming growth factor blockade treats diabetes-related kidney disease

Drug Delivery - Electroendocytosis guides therapeutic molecules into cells

Drug Resistance - Oblimersen antagonizes Bcl-2 to treat small cell lung cancer

Drug Resistance - Small interfering RNAs that target the MDR1 gene reverse multidrug resistance

Endocrinology - Adiponectin may treat vascular disorders related to obesity

Epstein-Barr Virus - EBNA-2 gene variant may play role in pathogenesis of oral hairy leukoplakia

Finance - Cancer company reports Q2 revenues of $212,000, down from same time last year

Finance - Genomic-analysis technology company reports improved financial results

Finance - Telomerase technology company reports Q2 loss of $8.9 million

Gene Regulation - BCNU promotes the death of oligodendroglioma-derived cells

Genetics - Exploiting gene mutations may combat osteoporosis and obesity

Genomics - CodY is activated by direct interaction with branched-chain amino acids

Genomics - Effective liver cell transduction relies on viral second-strand DNA synthesis

Genomics - Nucleophosmin partners with nuclear factor-kappa B to activate the SOD2 gene

Immunology - Cells engineered to secrete soluble CD70 boost antitumor immunity

Immunology - Interferon receptor regulation enhances the efficacy of cancer therapy

Leiomyoma - Early growth response-1 may have gene therapy potential for uterine fibroids

Macular Degeneration - Ophthalmology company files IND for therapeutic RNAi

Muscular Dystrophy - Forced dystrophin expression improves calcium handling in muscle cells

Neuroscience - Enzyme restoration prevents neuropathology in murine models of Hurler syndrome

Neuroscience - Oligonucleotide decoys modulate trauma response in the nervous system

Oncogenesis - DLEU2 is an antisense regulator of human and murine RFP2/LEU5 genes

Orthopedics - Orthopedic products company names new member to board of directors

Pancreatic Cancer - Triplex-forming oligonucleotide curtails the oncogene Ki-ras

Parkinson Disease - FDA clears gene therapy trial for Parkinson disease

Personnel - Bioscience company appoints Dale Ando VP of therapeutic development, CMO

Personnel - Cell-therapy company announces executive appointments

Personnel - Riaz Bandali joins board of electroporation company

Poxvirus Vaccine - Understanding of poxvirus pathogenesis advanced by deleting viral genes

Recombinant Research - A novel recovery approach for separation and concentration is described

Renal Cell Carcinoma - Bcl-2 antisense nucleotide sensitizes interferon-resistant renal cancer to Fas

Rheumatology - Early experimental osteoarthritis surrenders to gene therapy

Transfection - Virus-specific properties encourage brain cell gene transfer

Ulcerative Colitis - Enrollment continues in retreatment phase of Nuvion trial

Vaccine Delivery - Drug delivery systems reviewed

Vector Development - Photochemical transfection enhances the cytotoxicity of suicide gene therapy

Vectors - X marks the spot: Vector insertion is viral-specific

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