Oncogenesis
DLEU2 is an antisense regulator of human and murine RFP2/LEU5 genes
Published in Gene Therapy Weekly, September 9th, 2004
According to a study from Sweden, "our group previously identified two novel genes, RFP2/LEU5 and DLEU2, within a 13q14.3 genomic region of loss seen in various malignancies. However, no specific inactivating mutations were found in these or other genes in the vicinity of the deletion, suggesting that a nonclassical tumor-suppressor mechanism may be involved."
"Here, we present data showing that the DLEU2 gene encodes a putative noncoding antisense RNA, with one exon directly overlapping the first exon of the RFP2/LEU5 gene in the opposite orientation. In addition, the RFP2/LEU5...
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Source: Gene Therapy Weekly (2004-09-09)
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