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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . September 16th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cardiomyopathy - Partial-heart dystrophin gene transfer may correct hereditary heart disease

Immunology - Retinal transduction does not generate immune tolerance to transgene products

Neuroscience - Dual-cell, dual-gene therapy provides neuroprotection against excitotoxicity

Oncology - Virus-mediated p14(ARF) expression prompts apoptosis in osteosarcoma cells

Pulmonary Medicine - Adenovirus vectors trigger survival signals in the lungs

AIDS/HIV Vaccine - Camelized VH intrabodies against vif neutralize HIV-1 infectivity

Asthma - Company reaches clinical milestone related to IL-9 antibody alliance

Bacterial Infection - Biopharmaceutical company announce milestones in StaphVAX development

Bioregulation - Engineered riboregulators may be able to control gene expression

Business Update - Genetics company changes corporate identity to Icoria, Inc.

Cancer Immunotherapy - T cells with dual receptors suppress cancer growth

Cancer Therapy - Biopharmaceutical company announces positive results in cancer management trial

Cancer Therapy - Neovastat activates signals that destroy fibrin provisional matrices

Cardiology - Study links physiologic phenotype with defined genotype

Collaborations - Biotechcompany and Novosom enter collaboration and commercial option agreement

Collaborations - Icon Genetics and Berlex enter strategic alliance

Drug Delivery - External packing of DOTAP/DOPE and DC-Chol/DOPE lipoplexes is advantageous

Drug Delivery - Study supports electroporation-mediated DNA delivery without anesthesia

Drug Development - Chromatin insulators may increase the efficacy of gene therapy

Drug Development - Iowa researchers collaborate on RNAi technology for neurodegenerative disease

Drug Discovery - Company announces patent issuance for E2F transcription factor decoy technology

Drug Resistance - Suppressed Ras increases the sensitivity of glioma to cisplatin in vitro

Finance - Drug development company reports 2Q loss of less than $0.01 per share

Finance - Drug-discovery company announces second-quarter 2004 financial results

Finance - Electroporation-focused company report Q2 net loss of $2.2 million

Finance - Gene therapy company announces second-quarter loss of $2.3 million

Finance - RNAi company updates Q2, reports $0.2 million in revenues

Gene Delivery - Cholesterol ratio affects the interlamellar spacing of lipoplexes

Gene Regulation - Transcription factor CP2 helps activate mBMP4 in mesenchymal stem cells

Gene Silencing - Polycomb target gene silencing associates with histone H3 Lys 27 methylation

Gene Therapy - Data describe selectivity, efficacy, lack of toxicity of oncolytic adenovirus

Gene Transfer - Culture systems improve the study of gene function in inaccessible tissue

Gene Transfer - Pyridinium cationic lipids surpass the efforts of classic DTOAP-based formulas

Gene Transfer - Temperature and pH responsive polymers react to environmental changes

Heart Attack - Alliance to bring stem cell recruiting myoblast technology to clinic

Hematopoiesis - Definitive hematopoiesis requires mixed-lineage leukemia gene

Hepatology - Superoxide dismutase gene delivery protects murine livers from acute injury

Immunology - Bruton's tyrosine kinase gene knockout mice exhibit genomic alterations

Information Technology - Strategic alliance formed to develop gene expression simulation technnology

Medical Devices - Life science companies collaborate to develop automated solutions

Oncology - Pigment epithelium-derived factor gene therapy may treat liver cancer

Ophthalmology - Non-viral vectors deliver plasmid DNA to rabbit eye tissues

Pain Relief - Proangiogenic growth factor upregulates myoglobin to relieve ischemic muscles

Renal Cell Carcinoma - FDA grants fast-track status to temsirolimus

Stem Cell Research - Gene expression changes in course of neural progenitor cell differentiation

Therapeutic Proteins - Chromos enters into agreement with Centocor for development of cell lines

Vector Development - Novel biodegradable multi-block copolymers may be suitable for gene delivery

Virology - Virus known for its photo ops makes its movie screen debut

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