Published in Gene Therapy Weekly, September 16th, 2004
According to recent research from Germany, "grafting T cells with new antigen specificity by T cell receptor (TCR) gene transfer could greatly facilitate adoptive T cell immunotherapy. Little is known about how two TCR on one T cell influence each other. Among other reasons, this is often due to the fact that only one TCR specificity is known."
"We have genetically generated murine dual TCR T cells (OT-I/P14), specific for ovalbumin (ova257) and lymphocyte choriomeningitis virus glycoprotein (gp33). These cells retain both specificities and can be stimulated by either antigenic peptide to...
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