Gene Delivery
Cholesterol ratio affects the interlamellar spacing of lipoplexes
Published in Gene Therapy Weekly, September 16th, 2004
"Complexes (lipoplexes) between cationic liposomes and single-strand oligodeoxynucleotides (ODN) are potential delivery systems for antisense therapy. The nanometer-scale morphology of these assemblies is relevant to their transfection efficiency. In this work the monocationic lipid dioleoyloxytrimethylammoniumpropane, the neutral "helper" lipid cholesterol, and an 18-mer anti-bcl2 ODN were combined at different ratios," scientists in Israel report.
"The lipoplexes formed were characterized for the quantity of ODN bound, for the degree of lipid mixing, and for their size. The...
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Source: Gene Therapy Weekly (2004-09-16)
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