Gene Silencing
Polycomb target gene silencing associates with histone H3 Lys 27 methylation
Published in Gene Therapy Weekly, September 16th, 2004
"Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in vitro. However, it is not known if these histones are methylation targets in vivo because the human Polycomb repressive complex (PRC)2/3 complexes have not been studied in the context of a natural promoter because of the lack of known target genes," investigators in the United States report.
"Here we report the use of RNA expression arrays and CpG-island...
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Source: Gene Therapy Weekly (2004-09-16)
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