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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . September 23rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cancer Therapy - The C-terminal domain of tenomodulin has antiangiogenic properties

Pancreatic Cancer - The Wilms tumor gene is overexpressed in pancreatic ductal adenocarcinoma

Renal Cancer - von Hippel-Lindau promotes the self-destruction of renal carcinoma cells

Stem Cell Research - ABC transporter inhibitors enhance hematopoietic progenitor cell transduction

Suicide Gene Therapy - Mutant cytosine deaminase is an effective prodrug converter

Age Related Macular Degeneration - Phase 2 gene boosters protect the eye from photo-oxidative damage

Antisense Technology - Novel substitutions confer stability to oligonucleotides

Autoimmune Diseases - Natural peptide could play pivotal role in fight against autoimmune diseases

Brain Cancer - The telomerase inhibitor GRN163 overrides glioblastoma growth

Breast Cancer - Houston researchers examine breast cancer drug Herceptin, try to improve it

Cancer Gene Therapy - Telomerase promoter gene therapy jumpstarts lung cancer cell apoptosis

Cancer Research - Do RNA helicases contribute to cancer development and/or progression?

Cancer Therapy - Small molecule cancer therapy company presented data at cancer conference

Cervical Cancer - Adenovirus could aid local and systemic treatment of resistant disease

Clarification - Vascular biology support for the use of bevacizumab in colorectal cancer

Collaborations - Collaboration explores advanced applications of gene therapy for heart patients

DNA Vaccine Development - Nanoparticles developed for gene delivery to pulmonary epithelium

Diabetes Risk Factor - Resistin plays a physiological role in hepatic insulin resistance

Diagnostics - Noninvasive imaging may show telomerase promoter activity in humans

Drug Delivery - High density cationic lipid emulsions transfect adherent cells better

Drug Development - Protein kinase C eta inhibition potentiates TRAIL treatment of prostate cancer

Endocrinology - Rats fed ethinylestradiol reveal hormone-linked genetic changes in the liver

Gene Delivery - Cationic lipid-based emulsion offers long-term gene transfer with low toxicity

Gene Transfer - Electroporation improves the transfection of cells in murine wounds

Gene Transfer - Structure has little influence on lipoplex-mediated transfection efficiency

Genetic Engineering - Genetic modifications foster the study of cells growing on biomaterials

Genomics - Bioscience company provides identity DNA testing services for Kinsearch Registry

Genomics - German company brings gene synthesis to Asia with the help of Takara Bio Inc.

Genomics - Small interfering RNAs silence disease-related genes

Glaucoma - Mayo Clinic pioneers gene therapy delivery system for glaucoma

HIV/AIDS Gene Therapy - Novel target site for gene therapy may control/manage HIV-1 infection

Hematology - Factor VIII is retained in cellular intermediates during secretion

Huntington Disease - Results of gene variant data analysis released from Miraxion phase III trial

Immunology - Thioaptamers targeting NF-kappa B could stall pathological immune response

Mergers & Acquisitions - Protein therapeutics company acquires patent portfolio of PPL Therapeutics

Microcephaly - Protein involved in childhood disorder linked to cancer

Oncology - Chatechins manipulate several genes in order to suppress cancer

Oncovirus - Poliovirus receptor CD155 leaves glioma susceptible to oncolytic virus

Pain Medicine - Nitric oxide synthase antagonist abates nitrous oxide-induced antinociception

Parkinson Disease - First Parkinson gene therapy patient passes 1 year

Peripheral Arterial Disease - Doctors try to help body grow bypasses

Personnel - Gene-silencing company initiates planned expansion of its scientific staff

Personnel - Genetic and diagnostic company name chairman and founder as managing director

Protein Design - A new fibronectin hybrid protein chokes tumor growth with microthrombosis

Schizophrenia - Researchers identify gene associated with susceptibility to schizophrenia

Stem Cell Research - Genes induced by GDNF overproduction of neuronal progenitor cells characterized

Stem Cell Research - Known and novel transcripts overexpressed in hematopoietic stem cells identified

Stem Cell Research - San Francisco Chamber of Commerce endorses stem cell Proposition 71

Transplant Medicine - Interleukin-4 gene transfer delays acute splenic allograft rejection in rats

Tumor Suppression - TSLC1 gene induction initiates apoptosis in non-small-cell lung cancer cells

Vector Development - Biochemical elements slant conformational changes in bioresponsive polymers

Virology - Genetically modified viruses have long-term persistence in murine liver cells

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