Endocrinology
Rats fed ethinylestradiol reveal hormone-linked genetic changes in the liver
Published in Gene Therapy Weekly, September 23rd, 2004
"To identify genes showing responses to estrogen exposure in the livers of animals in a repeated oral dose toxicity study, dose-dependent gene expression profiles were analyzed using high-density oligonucleotide microarrays in Sprague-Dawley rats of both sexes administered ethinylestradiol (EE) for 28 days at concentrations of 0, 0.01, 0.1, and 1.0ppm in the diet," investigators in Japan report.
"Among 3776 genes examined, examples showing increased expression on EE-treatment were detected predominantly in females. Genes showing dose-dependent up-regulation with greater...
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Source: Gene Therapy Weekly (2004-09-23)
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