Hematology
Factor VIII is retained in cellular intermediates during secretion
Published in Gene Therapy Weekly, September 23rd, 2004
According to a study from Germany, "in mammalian cells, factor VIII (FVIII) secretion depends upon its interaction with chaperones of the endoplasmic reticulum (ER) and requires a unique ATP-dependent step to dissociate aggregates formed within the ER. To further elucidate mechanisms which might account for the inefficient secretion of recombinant FVIII (rFVIII), we have analyzed the pathways of recombinant full length (rFVIII-FL) and B-domain deleted (rFVIIIDeltaB) FVIII and compared these to the secretion route of native FVIII in primary hepatocytes."
"Using confocal laser scanning...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
Source: Gene Therapy Weekly (2004-09-23)
More Articles from Gene Therapy Weekly
- Cancer Therapy
The C-terminal domain of tenomodulin has antiangiogenic properties - Pancreatic Cancer
The Wilms tumor gene is overexpressed in pancreatic ductal adenocarcinoma - Renal Cancer
von Hippel-Lindau promotes the self-destruction of renal carcinoma cells - Stem Cell Research
ABC transporter inhibitors enhance hematopoietic progenitor cell transduction - Suicide Gene Therapy
Mutant cytosine deaminase is an effective prodrug converter - Age Related Macular Degeneration
Phase 2 gene boosters protect the eye from photo-oxidative damage - More from this issue of Gene Therapy Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
