Oncology
Chatechins manipulate several genes in order to suppress cancer
Published in Gene Therapy Weekly, September 23rd, 2004
"Catechins have been reported to possess anticancer activity in vitro and in vivo. To identify target genes that may be involved in the antitumorigenic effect of catechins, gene expression profiles in adherent human HT 29 colon carcinoma cells, in HT 29 spheroids and in epigallocatechin-3 gallate (EGCG)-treated HT 29 cells have been analyzed by high-density oligonucleotide microarrays," investigators in Germany report.
"Treatment of HT 29 cells with EGCG (2.5-50 mcm) resulted in a dose-dependent inhibition of spheroid formation of HT 29 cells. Forty transcripts were induced at least...
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Source: Gene Therapy Weekly (2004-09-23)
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