Stem Cell Research
ABC transporter inhibitors enhance hematopoietic progenitor cell transduction
Published in Gene Therapy Weekly, September 23rd, 2004
"High gene transfer efficiencies have been difficult to achieve in hematopoietic progenitor cells (HPCs) but are important to therapeutic success of HPC gene therapy. Efficient gene transfer is especially challenging with use of column-purified vector for clinical application, as opposed to centrifuged vector commonly used for research. We investigated novel approaches to increase transduction by using a clinically applicable protocol and quantities of column-purified lentiviral vector," scientists in the United States report.
"Recognizing the association of adenosine...
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Source: Gene Therapy Weekly (2004-09-23)
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