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Age Related Macular Degeneration

Phase 2 gene boosters protect the eye from photo-oxidative damage

Published in Gene Therapy Weekly, September 23rd, 2004

Phase 2 gene inducers protect the eye from photo-oxidative damage.

According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "the retinal pigment epithelial cell (RPE cell) layer protects the photoreceptors of the retina against oxidative stress. The decline of this capacity is believed to be a major factor in the impairment of vision in age-related macular degeneration. Exposure of human adult RPE cells to UV light at predominantly 320-400 nm (UVA light) in the presence of all-trans-retinaldehyde results in photo-oxidative cytotoxicity."

"Significant protection of...

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