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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . September 30th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Brain Cancer - iBAC system-mediated gene delivery stifles glioma cell growth

Coronary Artery Disease - Myocardial gene therapy initiates collateral development in occluded hearts

Head and Neck Cancer - Mutant p27 gene elicits anticancer effects in oral cancer cell lines

Immunology - Nucleosome-specific genetically engineered T cells staunch autoimmune disease

Metabolic Disease - Virus vector-mediated gene transfer corrects phenylketonuria in murine models

Alzheimer Disease - 12-Lipoxygenase blockade protects neurons from peptide-induced degeneration

Angiology - Superoxide dismutase gene transfer improves impaired aortic relaxation

Angioplasty - Inhibition may aid protective effect of IL-10 on postangioplasty restenosis

Anthrax - Researchers improve detection of diverse anthrax strains

Antisense Technology - Double-stranded complexes increase antisense oligonucleotide uptake

Autoimmune Disease - Genetically modified bone marrow cells produce tolerance to self antigens

Bladder Cancer - Novel gene therapy for bladder cancer shows strong results in animal studies

Cancer Therapy - Preclinical data demonstrate antitumor effects of T-oligo technology

Cardiology - Vasorin mediates the arterial response to injury

Collaborations - Pharmaceutical firm collaborates for depression gene program

Congenital Muscular Dystrophy - Laminin alpha1 chain transgenes correct genetically deficient mice

Drug Delivery - Collagen and methylated collagen gene carriers offer sustained transgenics

Drug Resistance - Cells with pleiotropic drug resistance can be targeted with anticancer therapy

Endocrinology - Gene expression profiling classifies parathyroid growths

Epilepsy - Pharma company receives tentative approval for Gabapentin capsules

Finance - Biopharmaceutical company reports limited strong revenue growth for FY 2004

Finance - Protien therapeutics company announces strong first half 2004 results

Gene Delivery - Outgrowth endothelial cells host gene vectors that target tumor vessels

Gene Expression - Molecular images track the activity of cancer gene therapy

Gene Suppression - Several strategies eliminate multidrug resistance gene expression

Gene Therapy - Modular protein engineering safer than viral vectors for gene therapy

Gene Therapy - RNA interference is a potent tool for gene-specific therapeutics

Gene Transfer - Centrifugation concentrates retroviruses used for transfection

Gene Transfer - Inflammation constrains a key gene therapy receptor on endothelial cells

Gene Transfer - Nuclear images monitor the efforts of PEGylated polyethylenimine vectors

Genomics - Phenotype suggests a prime function for Sox11 in tissue remodeling

Geriatrics - Improved vector systems will help patients with neurological disorders

HIV/AIDS - HIV vaccine progresses towards next phase

HIV/AIDS Research - SIV vaccine study data presented at AIDS Vaccine 2004

Human Growth Hormone - FDA defers decision on Omnitrope application

Immunology - Sphingosine kinase 1 knockdown vanquishes proinflammatory mediators

Information Technology - Bioinformatic company announces marketing alliance with Science-Partners

Medical Device - New miniaturized cardiovascular ultrasound announced

Muscular Dystrophy - Biopharmaceutical company awarded grant from muscular dystrophy association

Mutagenesis - Screenings for redundancies could cure many genetically-related disorders

Neurodegeneration - Neural stem cells have the potential for reconstructing damaged nervous systems

Neuroscience - Glial cell line-derived neurotrophic factor lowers tyrosine hydroxylase levels

Oncology - RNA molecules have shown promise as cancer therapy

Parkinson Disease - FDA approves Parcopa orally dissolving tablets for Parkinson disease

Parkinson Disease - Proteins delivered via engineered virus prevented loss of nerve cells

Peripheral Artery Disease - Clinical trial begins for therapy designed to grow new blood vessels

Reproductive Medicine - siRNA Expression vector useful for gene silencing in preimplantation embryo

Stem Cell Research - Genetically altered embryonic stem cells acquire dopaminergic neuronal traits

Stem Cell Research - Novel system characterizes the expression of totipotency-specific genes

Vascular Gene Therapy - NIH awards grant to conduct research for vascular gene delivery

Vector Development - Cyclodextrin-modified polyethylenimine polymers deliver genes without toxicity

Vector Development - Lipoplexes bearing triantennary galactosyl ligand strengthen gene transfer

Vectors - FIV-based lentiviral vector used for gene delivery to treat metabolic diseases

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