Brain Cancer
iBAC system-mediated gene delivery stifles glioma cell growth
Published in Gene Therapy Weekly, September 30th, 2004
"The expression of genes from genomic loci can be relatively complex, utilizing exonic, intronic and flanking sequences to regulate tissue and developmental specificity. Infectious bacterial artificial chromosomes (iBACs) have been shown to deliver and express large genomic loci (up to 135 kb) into primary cells for functional analyses. The delivery of large genomic DNA inserts allows the expression of complex loci and of multiple splice variants," scientists writing in the journal Gene Therapy report.
"Herein, we demonstrate for the first time that an iBAC will deliver and...
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Source: Gene Therapy Weekly (2004-09-30)
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