Reproductive Medicine
siRNA Expression vector useful for gene silencing in preimplantation embryo
Published in Gene Therapy Weekly, September 30th, 2004
According to researchers in England, siRNAs "have become a powerful and widely used tool for the analysis of gene function in mammalian cells."
In their study, S. Haraguchi and colleagues at the University of Cambridge found that "the microinjection of an siRNA expression vector into the nucleus is an efficient and powerful method of specific gene silencing in preimplantation mouse embryos," and "used this method to examine the expression of two genes EGFP and Oct4."
"Vectors encoding siRNAs targeted against EGFP or Oct4 were...
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Source: Gene Therapy Weekly (2004-09-30)
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