Biochemistry
Oligonucleotide aggregation is important for toll-like receptor 9 activation
Published in Gene Therapy Weekly, October 7th, 2004
According to recent research published in the Journal of Biological Chemistry, "Toll-like receptor 9 (TLR9), a member of the interleukin-1 (IL-1) family of pathogen-associated molecular pattern receptors, is activated by unmethylated CpG-containing sequences in bacterial DNA or synthetic oligonucleotides (ODNs) in the endosomal compartment. The stimulation of an IL-1 response is thought to require the aggregation of its receptor."
"By analogy, we postulated that the potency of a TLR9 ligand should depend first on its ability to enter cells and gain access to TLR9 and...
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Source: Gene Therapy Weekly (2004-10-07)
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