Adverse Drug Effects
Calbindin-D-28K protects renal tubular cells from cyclosporine toxicity
Published in Gene Therapy Weekly, October 7th, 2004
According to a study from the United States, "cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium-dependent calpains and caspases. Calbindin-D-28k, a cytosolic calcium binding protein, has been used as an intracellular Ca2+ buffer to reduce calcium-mediated cytotoxicity in non-renal cells such as neuronal cells."
"We investigated the effects of gene transfer of calbindin-D-28k cDNA on CsA cytotoxicity and...
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Source: Gene Therapy Weekly (2004-10-07)
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