Vascular Occlusion
Monocyte chemoattractant protein-1 gene inhibition thwarts in-stent restenosis
Published in Gene Therapy Weekly, October 14th, 2004
According to a study from Japan, "in-stent restenosis results exclusively from neointimal hyperplasia due to mechanical injury and a foreign body response to the prosthesis. Inflammation mediated by monocyte chemoattractant protein-1 (MCP-1) might therefore underlie in-stent restenosis. We recently devised a new strategy for anti-MCP-1 gene therapy by transfecting an N-terminal deletion mutant of the MCP-1 gene into skeletal muscles."
"We used this strategy to investigate the role of MCP-1 in experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys....
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Source: Gene Therapy Weekly (2004-10-14)
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