Colorectal Cancer

Prostaglandin EP receptors targets for colorectal cancer treatment/prevention

Published in Gene Therapy Weekly, October 21st, 2004

Prostaglandin EP receptors are potential targets for colorectal cancer treatment and prevention.

According to a recent review published in the journal Molecular Cancer Therapeutics, "The importance of the prostaglandin (PG) synthesis pathway, particularly the rate-limiting enzymatic step catalyzed by cyclooxygenase, to colorectal carcinogenesis and development of novel anticolorectal cancer therapy is well established."

"The predominant PG species in benign and malignant colorectal tumors is PGE₂ . PGE₂ acts via four EP receptors termed EP1 to EP4. Recently," wrote M.A. Hull and colleagues, "EP receptors have been...

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Source: Gene Therapy Weekly (2004-10-21)

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