Transgenics
Mutant mice reveal the characteristics of pseudogenes
Published in Gene Therapy Weekly, October 21st, 2004
According to researchers in Japan, "we have earlier generated a mutant mouse in a course of making a transgenic line that exhibited interesting heterozygote phenotypes, which exhibited failure to thrive, severe bone deformities, and polycystic kidneys. This mutant mouse provided a clue to uncover a unique role of expressed pseudogenes. In this mutant the transgene was integrated into the vicinity of the expressing pseudogene of Makorin1 called Makorin1-p1."
"This insertion reduced transcription of the Makorin1-p1, resulting in destabilization of the Makorin1 mRNA in trans via a cis-acting RNA...
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Source: Gene Therapy Weekly (2004-10-21)
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