Published in Gene Therapy Weekly, October 28th, 2004
According to a study from France, "inducible gene expression systems have contributed significantly to the understanding of molecular regulatory networks. Here we describe a simple and powerful RNA interference-based method that can silence the expression of any transgene. We first used an IRES bicistronic lentiviral vector and showed that targeting the second cistron with a specific small interfering RNA (siRNA) resulted in silencing of both transgenes."
"We then inserted a siRNA minimal target sequence In the 3'-untranslated region (3'-UTR) of a transgene and showed that the...
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