Hypertension

Adeno-associated virus-mediated kallikrein gene therapy prevents cardiac injury

Published in Gene Therapy Weekly, October 28th, 2004

Adeno-associated virus-mediated kallikrein gene therapy prevents cardiac injury.

"Gene therapy of hypertension requires long-term expression of a therapeutic gene to achieve stable reduction of blood pressure. Human tissue kallikrein (HK) cleaves kininogen to produce a potent vasoactive peptide kinin, which plays an important role in the regulation of the cardiovascular and renal functions. In the present study, we have delivered human kallikrein cDNA with a recombinant adeno-associated virus (rAAV) vector to explore the potential therapeutic effects of kallikrein on hypertension and related secondary complications," scientists in the Peoples Republic of China...

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Source: Gene Therapy Weekly (2004-10-28)

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