Immunology
Promoter-based restriction would improve skeletal muscle tissue gene transfer
Published in Gene Therapy Weekly, October 28th, 2004
According to a study from the United States, "research has shown that the use of a muscle-specific promoter can reduce immune response and improve gene transfer to muscle fibers."
"We investigated the efficiency of direct and ex vivo gene transfer to the skeletal muscles of 6- to 8-week-old mdx mice by using two adenoviral vectors: adenovirus (AD) encoding the luciferase gene under the cytomegalovirus (CMV) promoter (ADCMV) and AD encoding the same gene under the muscle creatine kinase (MCK) promoter (ADMCK). Direct intramuscular injection of ADMCK triggered a lower immune...
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Source: Gene Therapy Weekly (2004-10-28)
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