Oncogenesis
Integrin-linked kinase may inhibit breast cancer metastasis
Published in Gene Therapy Weekly, October 28th, 2004
According to recent research published in the International Journal of Cancer, "allelic loss at the short arm of chromosome 11 is one of the most common and potent events in the progression and metastasis of breast cancer. Here, we present evidence that the integrin-linked kinase (ILK) gene maps to the commonly deleted chromosome 11p15.5 and suppresses malignant growth of human breast cancer cells both in vitro and in vivo."
"ILK is expressed in normal breast tissue but is downregulated in metastatic breast cancer cell lines and in advanced breast cancers. Transfection of wild-type...
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Source: Gene Therapy Weekly (2004-10-28)
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