Apoptosis
P63 and p73 not required for development and p53-dependent apoptosis of T cells
Published in Gene Therapy Weekly, October 28th, 2004
According to a study from the United States, "The recent discoveries of p63 and p73, homologs of the tumor suppressor p53, raised the possibility of a network of these family members governing cell cycle arrest and apoptosis in response to stress.
"However, mice lacking p73 show no tendency for spontaneous tumors, and mutations in p63 or p73 are rare in human tumors, rendering any obligate role of these genes in cell death and tumor suppression unclear."
"In an effort to reconcile these incongruent data," M. Senoo and coauthors reported, "we...
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Source: Gene Therapy Weekly (2004-10-28)
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