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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . November 4th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Bioreactors - Polycation-mediated precipitation captures plasmid DNA from alkaline lysate

Breast Cancer - The adenoviral type 5 E1A gene sensitizes breast tumors to paclitaxel

Pancreatic Cancer - Suppressed synthesis of HMGA1 protein treats pancreatic carcinomas in mice

Tumor Suppression - Low-voltage electroporation augments antiangiogenic cancer gene therapy

Vector Development - Herpesvirus-based vector guides fusion protein to cancer cells

Acute Myeloid Leukemia - Loss of clone with FLT3 gene mutation at relapse does not improve AML prognosis

Alzheimer Disease - Biotechcompany scientist presented with award from Alzheimer Association

Antibiotic Resistance - Biotech company working to address problem of antibiotic resistance

Antisense Technology - Antisense inhibitors of TRADD could modulate TNF-related pathologies

Antisense Technology - The antisense mRNA sONE offers endothelial-cell specific gene expression

Awards - Biotech firm lauds Nobel winner, announces olfactory-based government contract

Awards - Genetics products company named to Technology Fast 50 Program for Washington

Basal Cell Carcinoma - Gli proteins up-regulate expression of basonuclin in basal cell carcinoma

Breast Cancer - Well-differentiated breast tumors have more 16q loss than poorly differentiated

Cancer Research - Biopharma company announces update on trial of compound for advanced cancers

Cancer Research - Leukemia society awards two $5 million grants to develop anticancer therapies

Cancer Research - New therapy may counteract Paclitaxel resistance in cancer cells

Cancer Therapies - Pharma company presented six studies at cancer therapy conference

Cardiology - Electroporation of hepatocyte growth factor DNA treats cardiomyopathy

Cardiovascular Disease - Biosciences company enters collaboration to study genetics of heart disease

Collaborations - Biogen enters pharmacodiagnostic research collaboration

DNA Damage - p53-dependent transcription exhibits on and off responses after genotoxic stress

Dermatology - Biopharmaceutical company announces resutls of dermatological disorder trial

Drug Delivery - Low molecular weight chitosan fractions exhibit marked solubility

Drug Development - Biotechnology company files a request of re-examination of Benitec

Drug Development - Sense oligonucleotides targeting VEGF may help patients with ischemic tissues

Enzymology - Superoxide dismutase gene transfer may treat complex I deficiency disorders

Finance - Biotherapeutics announces third-quarter 2004 results

Finance - Company raises $12 million to fund gene therapy

Gastric Cancer - Expression of 7 ARP2/3 complex genes are decreased in gastric cancer

Gastric Cancer - KiSS-1 downregulation causes tumor invasion/worse prognosis in gastric cancer

Gene Expression - Genomics company announces gene study in human embryonic stem cells

Gene Profiling - Biological materials provider signs distribution agreement with GE Healthcare

Gene Promotion - Chimeric constructs target heterologous genes in cancer-derived cells

Gene Therapy - New grant awarded for anemia treatment

Gene Transfer - Selective electroporation leaves adipocytes receptive to plasmid DNA

Genetic Recombination - New study links recombination rate with fertility

Genomics - Comparative study of Legionnaire's disease published

Genomics - Magazine publishes article on locating centromeres in plants

Genomics - Nucleic acid amplification company announces adoption of Ovation Biotin System

Genomics - Partnership formed to identify DNA variation in 20 strains of a plant

Genomics - Research company collaborates with scientists on BAC clone from tomato genome

Geobacillus Stearothermophilus V - Thermostable cysteine synthase from G. stearothermophilus V characterized

HIV/AIDS Research - Host cell gene expression varies during HIV-1 latency or reactivation

Hepatitis - Study reports results of PegIntron and Rebetol combination therapy for hepatitis

Infectious Disease - Company awarded SIBR grant for infectious disease detection

Macular Degeneration - Pharma company announces data for ocular disorders trial

Melanoma - B-RAF is therapeutic target in melanoma

Mergers & Acquisitions - Therapeutics company sells subsidiary to Neurogenesis Biotech

Mutagenesis - CPD-photolyase adenovirus-mediated gene transfer tracks photorepair in situ

Natriuretic Peptides - Current assays require refinement

Neurology - Anti-glucocorticoid gene delivery restructures neuronal stress response

Oncology - Anticancer agent may help induce cancer cell death

Oncology - FDA grants fast-track designation for metastatic melanoma treatment

Oncology - Restoration of metastasis suppressor genes could abate cancer dissemination

Oncolysis - Viral properties can be incorporated into adenovirus-based cancer therapies

Osteoporosis - Study shows once-monthly Boniva increases bone density and reduces breakdown

Osteoporosis - Women with osteoporosis treated with Actonel have good bone mineralization

Osteosarcoma - Trichostatin A offers novel therapeutic strategy for osteosarcoma

Parkinson Disease - Drug development company reports positive Parkinson disease study results

Peripheral Arterial Disease - Angiogenesis therapy successful for artery disease

Personnel - Biopharma company appoints vice president clinical research and development

Personnel - Biotechnology company elects members to board of directors

Personnel - Research institute appoints researcher specializing in nervous disorders

Product Licensing - Life sciences company, Rubicon Genomics sign genome amplification agreement

RNA Research - Intron arrays shed light on antisense intronic RNA in malignancies

SARS Coronavirus - Highly infectious SARS-CoV reveals cell tropism/receptor expression correlation

Sly Syndrome - Gene therapy overcomes blood-brain barrier to treat CNS manifestations

Stem Cell Research - Discoverer of DNA structure defends stem cell research opens exhibit

Stem Cell Research - Harvard researchers seek OK to produce cloned human embryos

Stem Cell Research - New report evaluates importance of cell therapy

Stem Cell Research - Science magazine hosts discussion of debate on embryonic stem cell research

Stem Cell Research - Stem cell research company provides update on programs

Stem Cells Research - Companies ink agreement for ACE system in adult-derived stem-cell research

Type 1 Diabetes - CTLA4 may be a susceptibility gene for type 1 diabetes

Vaccine Development - Memory T cells boost the DNA vaccine adjuvant interleukin-2/immunoglobulin

Vector Detection - Microarray screening can supply a vast selection of transgene candidates

Vector Development - Influenza A virus hemagglutinin constructs tend to lose fusion activity

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