Published in Gene Therapy Weekly, November 11th, 2004
"Metalloproteinases and tissue inhibitor of metalloproteinases (TIMPs) are associated with tissue reorganization after injury. The up-regulation of TIMP-3 has recently been found in ischemic brain although its functional implications are unclear," researchers in the Peoples Republic of China report.
"In this study we show that overexpression of TIMP-3 by adenovirus-mediated gene transfer partially protects neurons against excitotoxic death induced by glutamate in culture," said R.B. Pi and colleagues, Sun Yat Sen University, Department of Pharmacology.
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