Central Nervous System
TIMP-3 gene transfer affords partial protection to cortical neurons in rats
Published in Gene Therapy Weekly, November 11th, 2004
"Metalloproteinases and tissue inhibitor of metalloproteinases (TIMPs) are associated with tissue reorganization after injury. The up-regulation of TIMP-3 has recently been found in ischemic brain although its functional implications are unclear," researchers in the Peoples Republic of China report.
"In this study we show that overexpression of TIMP-3 by adenovirus-mediated gene transfer partially protects neurons against excitotoxic death induced by glutamate in culture," said R.B. Pi and colleagues, Sun Yat Sen University, Department of Pharmacology.
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Source: Gene Therapy Weekly (2004-11-11)
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