Cushing Syndrome

GIPR regulatory genes are unlikely to underlie GIP-dependent Cushing syndrome

Published in Gene Therapy Weekly, November 11th, 2004

GIPR regulatory genes are unlikely to underlie gastric inhibitory polypeptide-dependent Cushing syndrome.

"Gastric inhibitory polypeptide (GIP)-dependent Cushing's syndrome (CS) results from the ectopic expression of non-inutated GIP receptor (hGIPR) in the adrenal cortex. We evaluated whether mutations or polymorphisms in the regulatory region of the GIPR gene could lead to this aberrant expression," researchers in Canada report.

"We studied 9.0 kb upstream and 1.3 kb downstream of the GIPR gene putative promoter (pProm) by sequencing leukocyte DNA from controls and from adrenal tissues of GIP- and non-GIP-dependent CS patients," wrote S.R. Antonini...

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Source: Gene Therapy Weekly (2004-11-11)

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