Neuroscience
In vivo plasmid DNA transfer identifies neurone-specific gene promoters
Published in Gene Therapy Weekly, November 11th, 2004
"We utilized the retrograde transport machinery of neurons to deliver naked plasmid DNA into the central nervous system. A 5.4-kb fragment of the glycine receptor (GlyR) alpha1 subunit gene was cloned and used to drive the expression of a construct encoding for the enhanced green fluorescent protein (EGFP)," scientists in Australia report.
"Injections of the plasmid DNA in the tongue of mice resulted in the expression of the marker protein in hypoglossal motor neurons, showing that the GlyRalpha1 promoter sequence is sufficient to drive expression of the transgene," said R....
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Source: Gene Therapy Weekly (2004-11-11)
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