Vector Development
Adenoviruses with alternate serotypes transduce glioma cell lines
Published in Gene Therapy Weekly, November 11th, 2004
According to a study from Sweden, "there is a need for improvement of the commonly used adenovirus vectors based on serotype 5. This study was performed on three adenovirus serotypes with a CAR-binding motif (Ad4p, Ad5p and Ad17p) and three non-CAR-binding serotypes (Ad11p, Ad 16p and Ad21p). The capacity of these alternative adenovirus vector candidates to deliver DNA into low-passage glioma cell lines from seven different donors was evaluated."
"The non-CAR-binding serotype Ad16p was the most efficient serotype with regard to import of its DNA, as well as initiation of hexon protein...
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Source: Gene Therapy Weekly (2004-11-11)
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