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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . November 18th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Cytotoxicity - Human caldesmon mitigates the injurious effects of adenovirus infection

Gene Delivery - Genome size and structure determine the infectivity of adenovirus vectors

Gene Silencing - Microscope-based cell array displays the effects of siRNA in living cells

Neurodegeneration - Caspase-9dn gene delivery may impede dopaminergic neuron degeneration

Vaccine Development - Gene vaccines lead immune response reactions in the desired direction

Alzheimer Disease - Synthetic peptide reduces beta-amyloid plaque formation in transgenic mice

Animal Studies - Better DNA cassette exchange should enhance the propagation of modified mice

Antiviral Therapies - Virus-mediated alpha interferon transduction stops woodchuck hepatitis virus

Arthritis - MRI data show monoclonal antibody treatment decreases spinal inflammation

Arthritis - MRI study shows treatment may stop structural damage in Ankylosing Spondylitis patients

Arthritis - Results from two REMICADE studies presented at conference

Bioterrorism - New microarray test funded by NIH

Breast Cancer - San Diego Susan Komen foundation affiliate presents 'Bras Down Broadway'

Business & Finance - Company provides Q3 update, reports on oncology, cardiovascular programs

Business Update - News service tracking Genzyme launched

Cancer Research - Exclusive license granted for measuring DNA methylation of the RASSF1A gene

Cystic Fibrosis - Biopharma company presentesresults of trial at cystic fibrosis conference

Diabetes Gentics - Scientists find gene that may cause diabetes

Drug Delivery - Trial evidences importance of pairing drug formulation and delivery device

Drug Development - Bioreactor company receives National Science Foundation grant

Drug Development - Epigenetic changes in hematopoietic malignancies offer novel treatment tactics

Drug Development - Pharma company completes humanization of 3G4 antibody

Finance - Biopharmaceutical company reports third quarter results

Finance - Biotech completes new financing

Gene Discovery - RNA polymerase III promoters make ribozymes more attractive for modifying genes

Gene Expression - Co-expressed long complementary RNAs augment gene silencing regimens

Gene Expression - Gene expression profiling explores hepatocyte/nonparenchymal cell interactions

Gene Regulation - RNA-directed DNA demethylation shows promise for modifying mammalian cells

Genetics - Company announces new, speedy gene detection method

Genetics - New coalition to support personalized medicine

Genetics and Genomics - Remark on blacks' 'genetic predisposition' for dying younger draws fire

Genomics - Trade association warns genetically engineered crops threaten consumer choice

Huntington Disease - Biotech company announces RNAi therapeutic development for Huntington disease

Imaging - Researchers using imaging system to study G protein-coupled receptor levels

Legal Issues - Microalgea products company files suit

Longevity - Mice live longer when they slim down after gene therapy

Malaria - Study shows Corixa's MPL adjuvant protected against uncomplicated malaria

Mergers & Acquisitions - Alzheimer disease therapeutic company to acquire Guildford Clinical Pharmacology

Neurology - U.S. patent awarded for technology used in gene therapy trial

Neuropathy - PDGF-B chain protein expression is a forerunner of SHIV encephalitis

Neuroscience - Protein induction is selective in in vitro models of the blood-brain barrier

Oncology - Gene expression profiles yield clinicopathological staging of colorectal cancer

Oncology - New cancer target the focus of monoclonal antibody treatment

Oncology - New technology prevents breast cancer development in transgenic mice

Personnel - Colin Scott, MD, joins glycobiology company

Personnel - Genetics company expands drug development leadership

Personnel - Yves Rosconi named president, chief executive officer of biotech company

Point Mutations - DNA strand bias is apparent during targeted gene repair

Prostate Cancer - Conditional deletion of Rb causes early stage prostate cancer

Prostate Cancer - Interference with SONIC HEDGEHOG-GLI1 signaling inhibits prostate cancer

Recombinant Research - Company reports Cumulase study results

Rheumatology - Studies offer genetic clues to rheumatoid arthritis

Sexual & Reproductive Health - FDA approves Luveris for concomitant use with Gonal-f

Transplant Medicine - Iowa University Hospitals committed to transplant program

Viral Hepatitis - Adenovirus vectors and clevudine beat woodchuck hepatitis virus-infected cells

Virology - A novel DNA prime-boosting regimen produces antiviral immunity in study models

Virology - Drugmaker and USAMRIID to study ATryn for viral hemorrhagic diseases

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