Cytotoxicity
Human caldesmon mitigates the injurious effects of adenovirus infection
Published in Gene Therapy Weekly, November 18th, 2004
According to recent research published in the American Journal of Physiology - Cell Physiology, "the cytoskeleton is critical to the viral life cycle. Agents like cytochalasin inhibit viral infections but cannot be used for antiviral therapy because of their toxicity. We report the efficacy, safety, and mechanisms by which gene delivery of human wild-type low-molecular-weight caldesmon (l-CaD) protects cell membrane integrity from adenovirus infection in a DF-1 cell line, an immortalized avian fibroblast that is null for l-CaD."
"Transfection with an adenovirus...
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Source: Gene Therapy Weekly (2004-11-18)
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