Gene Expression
Co-expressed long complementary RNAs augment gene silencing regimens
Published in Gene Therapy Weekly, November 18th, 2004
"The use of long double-stranded RNA (dsRNA) for gene silencing in mammalian cells has generally been restricted to embryonic cell types and proposed to induce non-specific effects on gene expression in differentiated cells," according to researchers in Australia.
"In this study, we report that foreign and endogenous gene expression can be regulated in immortalized human cell lines by co-expression of long complementary RNAs with the potential to form dsRNA. The observed gene silencing effect was transferable to recipient control cells, occurred independently of cytoplasmic Dicer...
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Source: Gene Therapy Weekly (2004-11-18)
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