Neuropathy
PDGF-B chain protein expression is a forerunner of SHIV encephalitis
Published in Gene Therapy Weekly, November 18th, 2004
"Chemokines and cytokines play a critical role in human immunodeficiency virus (HIV) infection, serving both to modulate virus replication and to recruit target cells to the site of infection," according to scientists writing in the American Journal of Pathology.
"Platelet-derived growth factor (PDGF), a mitogen and chemoattractant for a wide variety of cells, is secreted by macrophages. Since macrophages are the target cells for lentiviral infection in the brain and PDGF is a known inducer of macrophage chemoattractant protein-1 (MCP)-1, a potent chemokine closely...
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Source: Gene Therapy Weekly (2004-11-18)
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