Published in Gene Therapy Weekly, November 25th, 2004
"Chromosome 9p21 is frequently deleted in many cancers. Previous reports have indicated that 9p21 LOH is an uncommon finding in neuroblastoma (NB), a tumor of childhood. We have performed an extensive analysis of 9p21 and genes located in this region (cyclin-dependent kinase inhibitor 2A-CDKN2A/p16(INK4a), CDKN2A/p14(ARF), CDKN2B/p15(INK4b), MTAP, interferon alpha and beta cluster)," researchers in Spain report.
"LOH was detected in 16.4% of 177 NB. The shortest region of overlap (SRO) was identified between markers D9S1751 and D9S254, at 9p21-23, a region telomeric to the...
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