Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . December 2nd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Bone Marrow Transplantation - Suicide gene constructs may be effective graft-versus-leukemia therapy
Gene Exression - CpG-reduced DNA vectors support long-term transgene expression
Gene Repair - Ribozyme-mediated RNA repair reverses dysfunctional p53 in cancer cells
Programmed Cell Death - Apoptotic death in B- and T-lymphocytes can be quantified with a new assay
Tumor Inhibition - CD25 T cell depletion and interleukin-12 gene transfer staunch melanoma growth
Antisense Technology - Suppressed E1AF limits the invasiveness of cervical cancer
Arrhythmia - "Painting" technique successfully transfers gene therapy to heart
Atherosclerosis - Low-density lipoprotein receptor gene therapy improves hypercholesterolemia
Breast Cancer - Death receptor 4 kills breast cancer cells despite the absence of TRAIL
Business & Finance - ATryn maker reports third-quarter net loss of $7.2 million
Business & Finance - Biosciences reports year-end results with narrowing losses
Business & Finance - Oral fluid diagnostics company announces financial results
Cancer Therapy - Biotech company announces issuance of reovirus patent
Cancer Therapy - Company achieves commercial scale of antigen for Provenge
Cardiology - Parvalbumin gene therapy ameliorates diastolic dysfunction in older rat hearts
Colon Cancer - Trials highlight Erbitux potential in first-line treatment of colorectal cancer
Diabetes - Research institute announces discovery on the virus' role in autoimmune disease
Diabetic Nephropathy - Data show FG-3019 improves kidney function in late-stage disease model
Duchenne Muscular Dystrophy - Muscular dystrophy models demonstrate exon skipping after gene transfer
Endocrinology - Regulatory T cells help new fusion constructs modulate diabetes in mouse models
Enzymology - Virus-mediated therapy corrects acute intermittent porphyria in murine models
Finance - Biosciences company reports 2004 third quarter, 9-month financial results
Finance - Biotech firm reports drop in revenue for Q3; BioSepra business sold
Finance - Cancer-focused pharmaceutical company reports third quarter 2004 results
Finance - Clinical-stage biotech company reports third quarter financial results
Finance - Gene expression company announces closing of series F financing
Finance - Genetics-based company reports third quarter 2004 financial results
Gene Inhibition - Therapy targeting interleukin-13 may be able to suppress fibrotic growth
Gene Manipulation - Alternative splicing efforts can be manipulated to rebalance Bcl-2 proteins
Gene Sequencing - Companies announce agreement to develop DNA sequencing instrumentation
Gene Silencing - Steroid and lipid conjugates of short interfering RNA improve liver cell uptake
Gene Transfer - Encapsulated cells secrete atrial natriuretic peptide for at least 6 months
Gene Transfer - Single bead screening is expected to optimize the mechanics of transfection
Gene Transfer - Temporary limb pressure drives short interfering RNA into skeletal muscles
Gene Transfer - The Sleeping Beauty transposon system directs therapeutic genes to tumor cells
Gene Transport - Transfection efficacy in the central nervous system depends on viral serotype
Genomics - Biotechnology company submits re-examiniation request for Benitec
Genomics - Supplier of identity DNA testing services comments on Justice for All Act
Glaucoma - Electroporation augments matrix metalloproteinase-3 transfection of the eye
Gynecology - Genes expressed in primary ovarian cancer cells lead treatment development
HIV/AIDS - Infectech, Inc., reports validation of mycobacteria avium complex kit
HIV/AIDS - Phase IIa study show Reverset potentially reduces HIV viral load
Hepatology - Pinocytosis and plasmid recycling obstruct liver cancer cell transfection
Herpes - License agreement for cancer-killing herpes virus concluded
Huntington Disease - RNA interference targeting the huntingtin gene is not linked to DNA methylation
Hypertension - Therapy bearing atrial natriuretic peptide DNA arrests rodent renal dysfunction
Immunization - Adenovirus vectors that express Fas ligand may treat allergic asthma
Information Technology - PlanetGene, online repository of codon optimized human genes for sale, launched
Informed Consent - Communication in the early era of gene transfer trials was unclear
Lung Cancer - Study indicates new uses for therapies in treating non-small cell lung cancer
Lung Cancer - Vesicular stomatitis virus and gemcitabine make lung tumors regress in mice
Market Analysis - Research analysis organization reviews transgenic manufacturing, licensing contracts
Melanocytes - PI3K mediates protection against TRAIL-induced apoptosis in melanocytes
Molecular Imaging - British prize awarded to Harvard-Robarts collaboration in molecular imaging
Multiple Sclerosis - Copaxone for treatment of multiple sclerosis subjected to independent review
Nerve Regeneration - Neurotrophic factors extend motoneuron survival but not axonal direction
Nerve Regeneration - Retinal neurons can regenerate after neurotoxic injury to rat retinas
Neuroscience - Microbubble-enhanced ultrasound augments central nerve system transfection
Oncology - Antisense regulation of antiapoptotic proteins sensitizes cancer to curcumin
Ovarian Cancer - MY018B gene alterations appear to be important in carcinogenesis
Ovarian Cancer - Pro-IL-18 isoform in ovarian tumors is resistant to caspase-1 and-4 processing
Pancreatic Cancer - Trichostatin A alters gene expression in pancreatic adenocarcinoma cells
Pediatric Oncology - Nuclear factor-kappa B blockade encourages neuroblastoma destruction
Personnel - Molecular test producer announces president for its U.S. subsidiary
Prostate Cancer - Insulator shielded PPT sequences augment adenovirus-mediated gene therapy
Prostate Cancer - Pharma companies awarded NIH grants for prostate cancer immunotherapies
Proteomics - Motility-related protein-1 cuts off tumor metastasis by suppressing Wnt signals
Recombinant Research - His-tags control protein conjugation while retaining functionality
Reconstructive Surgery - Muscular flaps transduced with bone morphogenetic protein generate bone markers
Sports Medicine - In situ gene transfer aids the repair of torn anterior cruciate ligaments
Stem Cell - Paper published on the origin and function of skin-derived precursors
Stem Cell Research - Biotech company comments on California initiative to support stem cell research
Stem Cell Research - Chemicon International acquires mouse embryonic stem cell product lines
Transplant Medicine - Michigan seeks medical records in failed kidney transplant case
Tumor Suppressor Gene - Thyroid hormone receptor beta gene functions as tumor suppressor gene
Tumor Vaccine - Therapeutic HER2/Neu DNA vaccine blocks the growth of murine tumors
Vaccine Development - Vector-based enhancement of ICAM-1 augments anti-tumor activity in mice
Vectors - Search for safe and gentle method
Virology - Species and strain differences guide adenovirus tropism in the liver
Wound Healing - Platelet-derived growth factor-B encourages the healing of diabetic wounds
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