Gene Vectors
Cytotoxicity and immunostimulation complicate lipoplex-mediated gene delivery
Published in Gene Therapy Weekly, December 9th, 2004
According to a study from Australia, "gor the past 15 years cationic liposomes have routinely been utilized for the delivery of nucleic acids such as plasmids and oligodeoxynucleotides to cells in culture and in vivo. These reagents are commercially available or are formulated in-house. However, particularly in cultured cells, toxicity remains a significant problem, and this is confirmed by several in vivo findings."
"In addition, these complexes exhibit an immunostimulation effect, a phenomenon that may either be harmful or beneficial. Furthermore, lipoplexes have been...
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Source: Gene Therapy Weekly (2004-12-09)
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