Gene Therapy Weekly
Susan Hasty, Publisher
Table of Contents . . . December 16th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Gene Therapy Weekly | Other Publications
Gene Modification - Peptide-modified alginate surfaces enable re-engineered cells to flourish
Immunology - Local blockade of negative stimulatory molecules augments antitumor cytokines
Metastasis - Reovirus foils the growth of metastatic breast cancer brain lesions
Neurology - Combined gene therapy and cancer immunotherapy attack glioma in murine models
Vaccine Development - Naked sequence-stabilized mRNA vaccine generates immunity to diverse antigens
Addiction Medicine - c-Fos antisense oligodeoxynucleotide counteracts methamphetamine activity
Animal Studies - Mice produce transgenic progeny after in vivo germ line stem cell transduction
Anthrax - Drug demonstrates survival benefits when given after anthrax exposure
Apoptosis - H2AX phosphorylation at short telomeres in T cells and fibroblasts demonstrated
Awards - University of Tokyo scientist granted second Sankyo Takamine Memorial Award
Biological Therapy - Autologous antitumor lymphocytes regress metastatic melanoma in cancer patients
Bioreactors - Ion exchange chromatography produces clinical grade viral vector stock
Business Update - Company announces termination of Genasense agreements by Aventis
Cancer Therapy - Drug-discovery alliance enters phase I clinical trials in cancer
Cancer Therapy - G-quartet oligonucleotides targeting Stat3 protein fight cancer growth
Chronic Lymphocytic Leukemia - Novel DNA cross-linking agent has potent/selective cytotoxicity in CLL B cells
DNA Research - H-1 paramagnetic relaxation enhancement characterizes protein-DNA interactions
Drug Development - Pharmaceutical company announces new research collaboration
Endocrinology - Thyroid transcription factor-1 boosts radioiodide retention in thyroid cancer
Enzymology - Telomerase-transduced cells may treat human diseases
Expression Vectors - One-step recombination technology generates desired adenoviral genomes
Finance - Biotech raises $410,000 in non-brokered private placement
Finance - Research tools producer reports third quarter and year-to-date 2004 results
Gastroenterology - NK4 staunches gastric cancer-related peritoneal metastasis in mice
Gene Expression - New amplification technology for gene-expression analysis announced
Gene Silencing - In vivo demonstration of RNAi via systemic delivery announced
Gene Transfer - Isolated hepatic perfusion provides a safe haven to adenoviral vectors
Gene Transfer - Key factors improve the efficacy of non-viral transfection in osteoblasts
Gene Transfer - Nonviral vectors transfer genes without stimulating the immune system
Gene Transfer - Therapy combining adenovirus vectors has increased transduction efficiency
Gene Vector - Kinase knockdown vectors now include multigenics
Geriatrics - Interleukin-7 restores early thymopoiesis but does not stop thymic involution
Heart Disease - Genetics company announces publication of gene-therapy approach to heart disease
Hematology - Extended beta-globin locus control region elements prolong transgene expression
Information Technology - Webware for analysis and reporting chromosomal data from array CGH launched
Medical Devices - Mount Sinai medical school installs single molecule analyzer in life science lab
Neuroscience - P311 hastens facial nerve regeneration following injury
Oncology - Biotech company announces initiation of Phase II trial for cancer treatment
Orthopedics - Genes can transduce tendon-bone insertion sites after transplantation
Prostate Cancer - Coding sequence determined for orthologs of prostate cancer susceptibility gene
Prostate Cancer - Ovine atadenovirus guides gene-directed enzyme prodrug therapy to cancer cells
Pulmonary Medicine - Lentivirus-mediated gene transfer has the potential to treat cystic fibrosis
RNA Research - Electroporation improves the success of embryonic stem cell transfection
Renal Cell Carcinoma - HIF1A gene polymorphisms associated with renal cell carcinoma phenotype
Stem Cell Research - Hematopoietic stem cells are highly receptive to adenovirus type 11p
Transfection - Lipids containing acylhydrazone linkers conduct acid-sensitive gene delivery
Transplant Medicine - Young transplant patient celebrates her first real Thanksgiving
Vaccine Development - Gene-gun DNA vaccination intensifies RSV-induced lung pathology in mice
Vaccine Development - Protein to antigen fusion heightens the efficacy of DNA cancer vaccine
Virology - Prototypic foamy virus vectors exhibit transduction advantages
Virology - Self-inactivating vectors outpace those that feature long terminal repeats
Vision Loss - Oligonucleotide control of VEGF expression stops choroidal neovascularization
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