Gene Transfer
Nonviral vectors transfer genes without stimulating the immune system
Published in Gene Therapy Weekly, December 16th, 2004
"The vectors for gene delivery are usually classified as viral and nonviral vectors. While the viral vectors are very efficient in transducing cells, safety concerns regarding their use in humans make nonviral vectors an attractive alternative. Among the nonviral vectors, the lipoplexes (complexes of cationic liposome/pDNA) are the most studied and represent the most promising approaches for human clinical trials," researchers in the United States report.
"However, an inflammatory response is invariably associated with administration of the lipoplexes, which must be avoided in the...
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Source: Gene Therapy Weekly (2004-12-16)
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