Vaccine Development
Protein to antigen fusion heightens the efficacy of DNA cancer vaccine
Published in Gene Therapy Weekly, December 16th, 2004
"Delivery of antigens by injection of the encoding DNA allows access to multiple antigen-presenting pathways. Knowledge of immunological processes can therefore be used to modify construct design to induce selected effector functions. Expression can be directed to specific intracellular sites, and additional genes can be fused or co-delivered to amplify responses," researchers in England state.
"Therapeutic vaccination against cancer adds a requirement to overcome tolerance and to activate a weakened immune repertoire. Induction of CD4+ T helper cells is critical for both...
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Source: Gene Therapy Weekly (2004-12-16)
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