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Gene Therapy Weekly

Susan Hasty, Publisher

Table of Contents . . . December 23rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Gene Therapy Weekly | Other Publications

Brain Cancer - Co-expressed genes in virus-driven therapy block glioma invasion

Diabetes Prevention - Gene-modified stem cells prevent type 1 diabetes in murine models

Fetal Development - Non-viral gene transfer tracks gene expression in murine embryos

Gene Promoters - G-quadruplex ligands may stop c-myc activity in tumor cells

Oncology - Sodium channel subunit beta gene delivery complements anticancer therapy

Amyotrophic Lateral Sclerosis - Promising results seen in the battle against incurable muscle disease

Antisense Technology - Egr-1 antisense molecules interfere with fear conditioning in rats

Autoimmune Diseases - Collaboration to develop antibodies for autoimmune diseases announced

Breast Cancer - Novel protein pathway linked to aggressive progression of breast cancer

Business & Finance - Glycotex Inc. receives additional capital for development of Glucoprime

Business & Finance - Molecular imaging services provider announces financial results

Business & Finance - Radiological interpretation software developer raises capital

Business Update - Partnership to combine information technology with biotech research formed

Cancer Therapy - Coramsine proven effective in treating mesothelioma in a mouse model

Cholera - Association of cytoskeleton with cholera toxin-ganglioside complex

Collaborations - Companies to develop HIV vaccine

Collaborations - Companies to offer pharmacogenomic technologies for oncology drug development

Colon Cancer - Antibody developed that penetrates mutant p53 colon cancer cells and binds p53

Congestive Heart Failure - Scientists use gene therapy to rescue failing hearts in animals

Diagnostics - German researchers publish results on DR-70 cancer test showing high sensitivity

Diagnostics - Infectech engages Lake Erie Research Institute for FDA submissions

Diagnostics - Patent issued for optical waveguides and molecular diagnostics device

Distribution Agreement - Exclusive RNAi distribution agreement for Japan announced

Drug Delivery - Peripheral tissues express transgenes after oral polyplex-based DNA vaccination

Enzymology - Sleeping Beauty transposase can be altered to improve genetic research

Finance - Gene therapy company reports Q3 net loss of $3.7 million

Gastroenterology - Apolipoprotein(A) kringles limit colorectal cancer liver metastasis in mice

Gene Transfer - Central leptin gene therapy shows promise for diminishing obesity

Gene Transfer - Copper/zinc superoxide dismutase enhances VEGF synthesis

Gynecology - Ether a go-go is a biomarker for human cervical cancer

HIV/AIDS Therapy - New cell therapy can make HIV its own worst enemy

Head and Neck Cancer - Interleukin 12 gene therapy curtails squamous cell carcinoma growth in mice

Hematology - RARbeta2 expression is diminished in myelofibrosis with myeloid metaplasia

Hypertension - Lentiviral vectors bear clones that offer long-term ACE2 secretion

Hypertension - Novel gene transfer prevents enlarged heart, cardiac fibrosis

Infectious Disease - Nonreplicating genetically modified phages guide toxins to human pathogens

Leukemia - Interleukin-3 receptor is a target for antileukemic drugs

Leukemic Stem Cells - Leukemic stem cells are a novel therapy target

Licensing Agreement - Geron licenses nuclear transfer technology

Macular Degeneration - Myopic macular degeneration clinical trial initiated

Medical Education - Cancer center starts new graduate school

Medical Technology - Life science research tools maker signs distribution agreement with Belgium firm

Mutagenesis - The homologous recombination pathway propels gene repair activity

Neurodegeneration - DNA damage caused by altered uracil incorporation produces neuron apoptosis

Oncology - Gene expression in rat bladder cancer models shadows that of humans

Parkinson Disease - Gene therapy shows promise in model of brain disease

Physiology - Interaction seen between the enamel matrix proteins amelogenin and ameloblastin

Product Licensing - Human alpha interferon for second-line therapy approved for sale in Bulgaria

Prostate Cancer - International research team identifies gene that promotes prostate cancer

Proteomics - Pharma company announces results of study with human lactoferrin

Receptor Studies - Olfactory receptor genes show genomic location and spatial expression linkage

Stem Cell Transplantation - Study shows transplanted stem cells can prevent death of retina cells in mice

Stroke - Pharma companies to codevelop PDE4 inhibitors for vascular diseases

Trends - Analysis: CVD products market to see enormous growth in next 5 years

Viral Vectors - Atomic force microscopy identifies virus-specific interactions

Virology - New data supports the utility of telomerase activation for HIV/AIDS therapy

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